Cell junctions and extracellular matrix (Page 2)

Master’s-Level Cell Biology & Advanced Molecular Biology Notes 1. Definition Tight junctions (TJs) are specialized cell–cell adhesion and sealing complexes located near the apical region of epithelial and endothelial cells. They perform two major functions: 2. Location in Epithelial Cells Tight junctions are positioned close to the apical surface of epithelial cells. A simplified epithelial junctional complex is: The precise organization varies among tissues. 3. Major Functions Function Description Barrier Restricts paracellular movement Fence Maintains membrane polarity Selectivity Determines permeability to ions and solutes Cell adhesion Helps maintain epithelial integrity Signaling Participates in intracellular signaling Mechanosensing Responds to mechanical forces Tissue organization Maintains epithelial architectureRead More →